Design, synthesis and evaluation of novel 2, 3-disubstituted-4-(3H) quinazolinone derivatives

Synthesis of some new 2,3-disubstituted-4(3H)quinazolinone derivatives

Quinazolinones are interesting materials because of their valuable biological effects. In this study some new 2,3-disubstituted-4(3H)quinqzolinone derivatives were synthesized from anthranilic acid in six steps by introducing a new chiral center to the aliphatic side chain of the quinazolinone. In the last step, a single acylation on the hydrazine moiety afforded final compounds. The structures...

Synthesis and antileishmanial evaluation of some 2,3-disubstituted-4(3H)-quinazolinone derivatives

BACKGROUND Leishmaniasis is a neglected tropical parasitic diseases affecting millions of people around the globe. Quinazolines are a group of compounds with diverse pharmacological activities. Owing to their promising antileishmanial activities, some 3-aryl-2-(substitutedstyryl)-4(3H)-quinazolinones were synthesized in good yields (65.2% to 86.4%). RESULTS The target compounds were synthesiz...

synthesis of some new 2,3-disubstituted-4(3h)quinazolinone derivatives

quinazolinones are interesting materials because of their valuable biological effects. in this study some new 2,3-disubstituted-4(3h)quinqzolinone derivatives were synthesized from anthranilic acid in six steps by introducing a new chiral center to the aliphatic side chain of the quinazolinone. in the last step, a single acylation on the hydrazine moiety afforded final compounds. the structures...

synthesis and antibacterial, antifungal and cytotoxic evaluation of some new 2,3-disubstituted 4(3h)-quinazolinone derivatives

Synthesis and Spectral Characterization of Novel 2, 3-Disubstituted Quinazolin-4(3H) one Derivatives

New series of 2,3-disubstituted quinazolin-4(3H)one were synthesized via the reaction of the readily obtainable 2-thioxo-3-phenyl-quinazolin-4(3H)one 1 with ethyl chloroacetate followed by hydrazinolysis to afford the hydrazide 3 which allowed to react with different electrophilic reagents such as carbon disulphide, phenyl isothiocyanate, β-diketones, anhydrides, acrylonitrile, ethyl cinnamate,...